Targeting the Polyadenylation Signal of Pre-mRNA: A New Gene Silencing Approach for Facioscapulohumeral Dystrophy

Facioscapulohumeral dystrophy (FSHD) is characterized by the contraction of the D4Z4 array located in the sub-telomeric region of the chromosome 4, leading to the aberrant expression of the DUX4 transcription factor and the mis-regulation of hundreds of genes. Several therapeutic strategies have bee...

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Detalles Bibliográficos
Autores principales: Marsollier, Anne-Charlotte, Joubert, Romain, Mariot, Virginie, Dumonceaux, Julie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983732/
https://www.ncbi.nlm.nih.gov/pubmed/29751519
http://dx.doi.org/10.3390/ijms19051347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983732/
https://www.ncbi.nlm.nih.gov/pubmed/29751519
http://dx.doi.org/10.3390/ijms19051347

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