Downregulation of the S1P Transporter Spinster Homology Protein 2 (Spns2) Exerts an Anti-Fibrotic and Anti-Inflammatory Effect in Human Renal Proximal Tubular Epithelial Cells

Sphingosine kinase (SK) catalyses the formation of sphingosine 1-phosphate (S1P), which acts as a key regulator of inflammatory and fibrotic reactions, mainly via S1P receptor activation. Here, we show that in the human renal proximal tubular epithelial cell line HK2, the profibrotic mediator transf...

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Detalles Bibliográficos
Autores principales: Blanchard, Olivier, Stepanovska, Bisera, Starck, Manuel, Erhardt, Martin, Römer, Isolde, Meyer zu Heringdorf, Dagmar, Pfeilschifter, Josef, Zangemeister-Wittke, Uwe, Huwiler, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983760/
https://www.ncbi.nlm.nih.gov/pubmed/29772789
http://dx.doi.org/10.3390/ijms19051498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983760/
https://www.ncbi.nlm.nih.gov/pubmed/29772789
http://dx.doi.org/10.3390/ijms19051498

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