Modulating Chemosensitivity of Tumors to Platinum-Based Antitumor Drugs by Transcriptional Regulation of Copper Homeostasis

Platinum (Pt)-based antitumor agents have been effective in treating many human malignancies. Drug importing, intracellular shuffling, and exporting—carried out by the high-affinity copper (Cu) transporter (hCtr1), Cu chaperone (Ato x1), and Cu exporters (ATP7A and ATP7B), respectively—cumulatively...

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Detalles Bibliográficos
Autores principales: Lai, Yu-Hsuan, Kuo, Chin, Kuo, Macus Tien, Chen, Helen H. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983780/
https://www.ncbi.nlm.nih.gov/pubmed/29772714
http://dx.doi.org/10.3390/ijms19051486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983780/
https://www.ncbi.nlm.nih.gov/pubmed/29772714
http://dx.doi.org/10.3390/ijms19051486

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