Cargando…

The cJUN NH(2)-terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation

Breast cancer is the most commonly diagnosed malignancy in women. Analysis of breast cancer genomic DNA indicates frequent loss-of-function mutations in components of the cJUN NH(2)-terminal kinase (JNK) signaling pathway. Since JNK signaling can promote cell proliferation by activating the AP1 tran...

Descripción completa

Detalles Bibliográficos
Autores principales:	Girnius, Nomeda, Edwards, Yvonne JK, Garlick, David S, Davis, Roger J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984035/ https://www.ncbi.nlm.nih.gov/pubmed/29856313 http://dx.doi.org/10.7554/eLife.36389

Ejemplares similares

The cJUN NH(2)-terminal kinase (JNK) pathway contributes to mouse mammary gland remodeling during involution
por: Girnius, Nomeda, et al.
Publicado: (2018)

Role of the MAPK/cJun NH(2)-terminal kinase signaling pathway in starvation-induced autophagy
por: Barutcu, Seda Avcioglu, et al.
Publicado: (2018)

NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte
por: Udden, SM Nashir, et al.
Publicado: (2019)

cJun N-terminal kinase (JNK) phosphorylation of serine 36 is critical for p66Shc activation
por: Khalid, Sana, et al.
Publicado: (2016)

Excitatory transmission onto AgRP neurons is regulated by cJun NH(2)-terminal kinase 3 in response to metabolic stress
por: Vernia, Santiago, et al.
Publicado: (2016)

Selection and Characterization of a DNA Aptamer That Can Discriminate between cJun/cJun and cJun/cFos
por: Walters, Ryan D., et al.
Publicado: (2014)

Regulation of c-Jun NH(2)-terminal Kinase ( Jnk) Gene Expression during T Cell Activation
por: Weiss, Linda, et al.
Publicado: (2000)

c-Jun NH(2)-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8(+) T Cell Activation
por: Conze, Dietrich, et al.
Publicado: (2002)

In vitro and in vivo neuroprotective effects of cJun N-terminal kinase inhibitors on retinal ganglion cells
por: Kim, Byung-Jin, et al.
Publicado: (2016)

Selective antagonism of cJun for cancer therapy
por: Brennan, Andrew, et al.
Publicado: (2020)

c-Jun NH(2)-Terminal Kinase (JNK)1 and JNK2 Signaling Pathways Have Divergent Roles in CD8(+) T Cell–mediated Antiviral Immunity
por: Arbour, Nathalie, et al.
Publicado: (2002)

C-Jun Nh(2)-Terminal Kinase (Jnk)1 and Jnk2 Have Similar and Stage-Dependent Roles in Regulating T Cell Apoptosis and Proliferation
por: Sabapathy, Kanaga, et al.
Publicado: (2001)

Regulation of c-Jun NH(2)-Terminal Kinase for Islet Transplantation
por: Noguchi, Hirofumi
Publicado: (2019)

c-JUN n-Terminal Kinase (JNK) Signaling in Autosomal Dominant Polycystic Kidney Disease
por: Smith, Abigail O., et al.
Publicado: (2022)

Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase
por: Schattauer, Selena S., et al.
Publicado: (2017)

Pharmacological c-Jun NH(2)-Terminal Kinase (JNK) Pathway Inhibition Reduces Severity of Spinal Muscular Atrophy Disease in Mice
por: Schellino, Roberta, et al.
Publicado: (2018)

Alarmins and c-Jun N-Terminal Kinase (JNK) Signaling in Neuroinflammation
por: Anfinogenova, Nina D., et al.
Publicado: (2020)

The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases
por: Chen, Jing, et al.
Publicado: (2021)

c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease
por: Smith, Abigail O., et al.
Publicado: (2021)

p27 transcriptionally coregulates cJun to drive programs of tumor progression
por: Yoon, Hyunho, et al.
Publicado: (2019)

RIP3 deficiency attenuated hepatic stellate cell activation and liver fibrosis in schistosomiasis through JNK-cJUN/Egr1 downregulation
por: Song, Li-Jun, et al.
Publicado: (2022)

Reciprocal signals between microglia and neurons regulate α-synuclein secretion by exophagy through a neuronal cJUN-N-terminal kinase-signaling axis
por: Christensen, Dan Ploug, et al.
Publicado: (2016)

Stressor-Like Effects of c-Jun N-Terminal Kinase (JNK) Inhibition
por: Clarke, Melanie, et al.
Publicado: (2012)

Platinum-Resistant Ovarian Cancer Is Vulnerable to the cJUN-XRCC4 Pathway Inhibition
por: Xu, Manman, et al.
Publicado: (2022)

Krox-20 inhibits Jun-NH(2)-terminal kinase/c-Jun to control Schwann cell proliferation and death
por: Parkinson, David B., et al.
Publicado: (2004)

The Prognostic Significance of Anisomycin-Activated Phospho-c-Jun NH2-Terminal Kinase (p-JNK) in Predicting Breast Cancer Patients’ Survival Time
por: Chen, Li, et al.
Publicado: (2021)

c-Jun N-terminal kinase (JNK) cooperates with Gsk3β to regulate Dishevelled-mediated microtubule stability
por: Ciani, Lorenza, et al.
Publicado: (2007)

Molecular docking of C-Jun-N-Terminal Kinase (Jnk) with amino-pyrimidine derivatives
por: Meenakumari, Krishnamoorthy, et al.
Publicado: (2020)

Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes
por: Yung, Justin Hou Ming, et al.
Publicado: (2020)

Inhibition of c-Jun NH(2)-terminal kinase or extracellular signal-regulated kinase improves lung injury
por: Lee, Hui Su, et al.
Publicado: (2004)

Activation of the c-Jun NH(2)-terminal kinase pathway by coronavirus infectious bronchitis virus promotes apoptosis independently of c-Jun
por: Fung, To Sing, et al.
Publicado: (2017)

cJun phosphorylation integrates calcium spike activity and tlx3 expression to regulate neurotransmitter specification
por: Marek, Kurt W., et al.
Publicado: (2010)

Activation of c-Jun N-Terminal Kinase (JNK) during Mitosis in Retinal Progenitor Cells
por: Ribas, Vinicius Toledo, et al.
Publicado: (2012)

C-Jun N-terminal kinase (JNK) isoforms play differing roles in otitis media
por: Yao, William, et al.
Publicado: (2014)

c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer’s Disease
por: Yarza, Ramon, et al.
Publicado: (2016)

Novel Tryptanthrin Derivatives with Selectivity as c–Jun N–Terminal Kinase (JNK) 3 Inhibitors
por: Schepetkin, Igor A., et al.
Publicado: (2023)

Specific effects of c-Jun NH2-terminal kinase-interacting protein 1 in neuronal axons
por: Tang, Shu, et al.
Publicado: (2016)

Anergic T cells are defective in both jun NH2-terminal kinase and mitogen-activated protein kinase signaling pathways
Publicado: (1996)

Matrix Survival Signaling: From Fibronectin via Focal Adhesion Kinase to C-Jun Nh(2)-Terminal Kinase
por: Almeida, Eduardo A.C., et al.
Publicado: (2000)

JNK-Dependent cJun Phosphorylation Mitigates TGFβ- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses
por: Sundqvist, Anders, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ttabma14rfnvsp832mhfckvl2o