Integrated genomics and proteomics to define huntingtin CAG length-dependent networks in HD Mice

To gain insight into how mutant huntingtin (mHtt) CAG repeat length modifies Huntington’s disease (HD) pathogenesis, we profiled mRNA in over 600 brain and peripheral tissue samples from HD knock-in mice with increasing CAG repeat lengths. We find repeat length dependent transcriptional signatures a...

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Detalles Bibliográficos
Autores principales: Langfelder, Peter, Cantle, Jeffrey P., Chatzopoulou, Doxa, Wang, Nan, Gao, Fuying, Al-Ramahi, Ismael, Lu, Xiao-Hong, Ramos, Eliana Marisa, El-Zein, Karla, Zhao, Yining, Deverasetty, Sandeep, Tebbe, Andreas, Schaab, Christoph, Lavery, Daniel J., Howland, David, Kwak, Seung, Botas, Juan, Aaronson, Jeffrey S., Rosinski, Jim, Coppola, Giovanni, Horvath, Steve, Yang, X. William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984042/
https://www.ncbi.nlm.nih.gov/pubmed/26900923
http://dx.doi.org/10.1038/nn.4256

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984042/
https://www.ncbi.nlm.nih.gov/pubmed/26900923
http://dx.doi.org/10.1038/nn.4256

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