Negative selection in tumor genome evolution acts on essential cellular functions and the immunopeptidome

BACKGROUND: Natural selection shapes cancer genomes. Previous studies used signatures of positive selection to identify genes driving malignant transformation. However, the contribution of negative selection against somatic mutations that affect essential tumor functions or specific domains remains...

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Detalles Bibliográficos
Autores principales: Zapata, Luis, Pich, Oriol, Serrano, Luis, Kondrashov, Fyodor A., Ossowski, Stephan, Schaefer, Martin H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984361/
https://www.ncbi.nlm.nih.gov/pubmed/29855388
http://dx.doi.org/10.1186/s13059-018-1434-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984361/
https://www.ncbi.nlm.nih.gov/pubmed/29855388
http://dx.doi.org/10.1186/s13059-018-1434-0

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