Cargando…

Module and individual domain deletions of NRPS to produce plipastatin derivatives in Bacillus subtilis

BACKGROUND: Plipastatin, an antifungal lipopeptide, is synthesized by a non-ribosomal peptide synthetase (NRPS) in Bacillus subtilis. However, little information is available on the combinatorial biosynthesis strategies applied in plipastatin biosynthetic pathway. In this study, we applied module or...

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Ling, Guo, Jianping, Fan, Yun, Ma, Zhi, Lu, Zhaoxin, Zhang, Chong, Zhao, Haizhen, Bie, Xiaomei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984369/
https://www.ncbi.nlm.nih.gov/pubmed/29855381
http://dx.doi.org/10.1186/s12934-018-0929-4