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Module and individual domain deletions of NRPS to produce plipastatin derivatives in Bacillus subtilis

BACKGROUND: Plipastatin, an antifungal lipopeptide, is synthesized by a non-ribosomal peptide synthetase (NRPS) in Bacillus subtilis. However, little information is available on the combinatorial biosynthesis strategies applied in plipastatin biosynthetic pathway. In this study, we applied module or...

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Detalles Bibliográficos
Autores principales:	Gao, Ling, Guo, Jianping, Fan, Yun, Ma, Zhi, Lu, Zhaoxin, Zhang, Chong, Zhao, Haizhen, Bie, Xiaomei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984369/ https://www.ncbi.nlm.nih.gov/pubmed/29855381 http://dx.doi.org/10.1186/s12934-018-0929-4

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