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UMI-count modeling and differential expression analysis for single-cell RNA sequencing

Read counting and unique molecular identifier (UMI) counting are the principal gene expression quantification schemes used in single-cell RNA-sequencing (scRNA-seq) analysis. By using multiple scRNA-seq datasets, we reveal distinct distribution differences between these schemes and conclude that the...

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Detalles Bibliográficos
Autores principales:	Chen, Wenan, Li, Yan, Easton, John, Finkelstein, David, Wu, Gang, Chen, Xiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Method
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984373/ https://www.ncbi.nlm.nih.gov/pubmed/29855333 http://dx.doi.org/10.1186/s13059-018-1438-9

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