LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons

Mutations in leucine-rich repeat kinase (LRRK2) are the most common cause of heritable Parkinson’s disease (PD), and the most common mutations in LRRK2 lead to elevated kinase activity. For these reasons, inhibitors targeting LRRK2 have been the subject of intense research and development. However,...

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Detalles Bibliográficos
Autores principales: Henderson, Michael X., Peng, Chao, Trojanowski, John Q., Lee, Virginia M. Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984465/
https://www.ncbi.nlm.nih.gov/pubmed/29855356
http://dx.doi.org/10.1186/s40478-018-0550-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984465/
https://www.ncbi.nlm.nih.gov/pubmed/29855356
http://dx.doi.org/10.1186/s40478-018-0550-0

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