Hydrogel delivery of lysostaphin eliminates orthopedic implant infection by Staphylococcus aureus and supports fracture healing

Orthopedic implant infections are a significant clinical problem, with current therapies limited to surgical debridement and systemic antibiotic regimens. Lysostaphin is a bacteriolytic enzyme with high antistaphylococcal activity. We engineered a lysostaphin-delivering injectable PEG hydrogel to tr...

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Detalles Bibliográficos
Autores principales: Johnson, Christopher T., Wroe, James A., Agarwal, Rachit, Martin, Karen E., Guldberg, Robert E., Donlan, Rodney M., Westblade, Lars F., García, Andrés J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984524/
https://www.ncbi.nlm.nih.gov/pubmed/29760099
http://dx.doi.org/10.1073/pnas.1801013115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984524/
https://www.ncbi.nlm.nih.gov/pubmed/29760099
http://dx.doi.org/10.1073/pnas.1801013115

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