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Hydrogel delivery of lysostaphin eliminates orthopedic implant infection by Staphylococcus aureus and supports fracture healing

Orthopedic implant infections are a significant clinical problem, with current therapies limited to surgical debridement and systemic antibiotic regimens. Lysostaphin is a bacteriolytic enzyme with high antistaphylococcal activity. We engineered a lysostaphin-delivering injectable PEG hydrogel to tr...

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Detalles Bibliográficos
Autores principales:	Johnson, Christopher T., Wroe, James A., Agarwal, Rachit, Martin, Karen E., Guldberg, Robert E., Donlan, Rodney M., Westblade, Lars F., García, Andrés J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2018
Materias:	PNAS Plus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984524/ https://www.ncbi.nlm.nih.gov/pubmed/29760099 http://dx.doi.org/10.1073/pnas.1801013115

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