Size-tagged preferred ends in maternal plasma DNA shed light on the production mechanism and show utility in noninvasive prenatal testing

Cell-free DNA in human plasma is nonrandomly fragmented and reflects genomewide nucleosomal organization. Previous studies had demonstrated tissue-specific preferred end sites in plasma DNA of pregnant women. In this study, we performed integrative analysis of preferred end sites with the size chara...

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Detalles Bibliográficos
Autores principales: Sun, Kun, Jiang, Peiyong, Wong, Ada I. C., Cheng, Yvonne K. Y., Cheng, Suk Hang, Zhang, Haiqiang, Chan, K. C. Allen, Leung, Tak Y., Chiu, Rossa W. K., Lo, Y. M. Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984542/
https://www.ncbi.nlm.nih.gov/pubmed/29760053
http://dx.doi.org/10.1073/pnas.1804134115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984542/
https://www.ncbi.nlm.nih.gov/pubmed/29760053
http://dx.doi.org/10.1073/pnas.1804134115

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