Size-tagged preferred ends in maternal plasma DNA shed light on the production mechanism and show utility in noninvasive prenatal testing

Cell-free DNA in human plasma is nonrandomly fragmented and reflects genomewide nucleosomal organization. Previous studies had demonstrated tissue-specific preferred end sites in plasma DNA of pregnant women. In this study, we performed integrative analysis of preferred end sites with the size chara...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Kun, Jiang, Peiyong, Wong, Ada I. C., Cheng, Yvonne K. Y., Cheng, Suk Hang, Zhang, Haiqiang, Chan, K. C. Allen, Leung, Tak Y., Chiu, Rossa W. K., Lo, Y. M. Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984542/
https://www.ncbi.nlm.nih.gov/pubmed/29760053
http://dx.doi.org/10.1073/pnas.1804134115

Ejemplares similares

Ejemplares similares