Insights into the structural dynamics of the bacteriophage T7 DNA polymerase and its complexes

The T7 DNA polymerase is dependent on the host protein thioredoxin (trx) for its processivity and fidelity. Using all-atom molecular dynamics, we demonstrate the specific interactions between trx and the T7 polymerase, and show that trx docking to its binding domain on the polymerase results in a si...

Descripción completa

Detalles Bibliográficos
Autores principales: Magill, Damian J., McGrath, John W., O’Flaherty, Vincent, Quinn, John P., Kulakov, Leonid A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984650/
https://www.ncbi.nlm.nih.gov/pubmed/29858666
http://dx.doi.org/10.1007/s00894-018-3671-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984650/
https://www.ncbi.nlm.nih.gov/pubmed/29858666
http://dx.doi.org/10.1007/s00894-018-3671-2

Ejemplares similares