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Insights into the structural dynamics of the bacteriophage T7 DNA polymerase and its complexes
The T7 DNA polymerase is dependent on the host protein thioredoxin (trx) for its processivity and fidelity. Using all-atom molecular dynamics, we demonstrate the specific interactions between trx and the T7 polymerase, and show that trx docking to its binding domain on the polymerase results in a si...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984650/ https://www.ncbi.nlm.nih.gov/pubmed/29858666 http://dx.doi.org/10.1007/s00894-018-3671-2 |