Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis

BACKGROUND: Paraspeckles are subnuclear bodies assembled on a long non-coding RNA (lncRNA) NEAT1. Their enhanced formation in spinal neurons of sporadic amyotrophic lateral sclerosis (ALS) patients has been reported but underlying mechanisms are unknown. The majority of ALS cases are characterized b...

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Detalles Bibliográficos
Autores principales: Shelkovnikova, Tatyana A., Kukharsky, Michail S., An, Haiyan, Dimasi, Pasquale, Alexeeva, Svetlana, Shabir, Osman, Heath, Paul R., Buchman, Vladimir L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984788/
https://www.ncbi.nlm.nih.gov/pubmed/29859124
http://dx.doi.org/10.1186/s13024-018-0263-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984788/
https://www.ncbi.nlm.nih.gov/pubmed/29859124
http://dx.doi.org/10.1186/s13024-018-0263-7

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