Proteolytic single hinge cleavage of pertuzumab impairs its Fc effector function and antitumor activity in vitro and in vivo

BACKGROUND: Proteolytic impairment of the Fc effector functions of therapeutic monoclonal antibodies (mAbs) can compromise their antitumor efficacy in the tumor microenvironment and may represent an unappreciated mechanism of host immune evasion. Pertuzumab is a human epidermal growth factor recepto...

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Detalles Bibliográficos
Autores principales: Hsiao, Hao-Ching, Fan, Xuejun, Jordan, Robert E., Zhang, Ningyan, An, Zhiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984793/
https://www.ncbi.nlm.nih.gov/pubmed/29859099
http://dx.doi.org/10.1186/s13058-018-0972-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984793/
https://www.ncbi.nlm.nih.gov/pubmed/29859099
http://dx.doi.org/10.1186/s13058-018-0972-4

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