3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1,2,4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation

Ulcerative colitis (UC) is a common inflammatory bowel disease that can destroy the integrity of the colon and increase the risk of colorectal cancer. Oxidative stress is one of the critical pathogenic factors for UC, further impairing the entire affected colon. The Nrf2-ARE signaling pathway plays...

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Detalles Bibliográficos
Autores principales: Xu, Li-Li, Liu, Tian, Wang, Lei, Li, Li, Wu, Yu-Feng, Li, Cui-Cui, Di, Bin, You, Qi-Dong, Jiang, Zheng-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985092/
https://www.ncbi.nlm.nih.gov/pubmed/29887940
http://dx.doi.org/10.1155/2018/3271617

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985092/
https://www.ncbi.nlm.nih.gov/pubmed/29887940
http://dx.doi.org/10.1155/2018/3271617

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