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Activation of Sirtuin 1 Attenuates High Glucose-Induced Neuronal Apoptosis by Deacetylating p53

Diabetes mellitus (DM) has been proven to be a key risk factor for cognitive impairment. Previous studies have implicated hippocampal neuronal apoptosis in diabetes-related cognitive impairment. However, the underlying mechanism remains unknown. Sirtuin 1 (SIRT1) is a protein deacetylase depended on...

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Detalles Bibliográficos
Autores principales:	Shi, Xiajie, Pi, Linhua, Zhou, Shanlei, Li, Xin, Min, Fangyuan, Wang, Shan, Liu, Zhenqi, Wu, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985296/ https://www.ncbi.nlm.nih.gov/pubmed/29892266 http://dx.doi.org/10.3389/fendo.2018.00274

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