Cargando…

IQ Domain-Containing GTPase-Activating Protein 1 Regulates Cytoskeletal Reorganization and Facilitates NKG2D-Mediated Mechanistic Target of Rapamycin Complex 1 Activation and Cytokine Gene Translation in Natural Killer Cells

Natural killer (NK) cells are innate lymphocytes that play essential roles in mediating antitumor immunity. NK cells respond to various inflammatory stimuli including cytokines and stress-induced cellular ligands which activate germline-encoded activation receptors (NKRs), such as NKG2D. The signali...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abel, Alex M., Tiwari, Aradhana A., Gerbec, Zachary J., Siebert, Jason R., Yang, Chao, Schloemer, Nathan J., Dixon, Kate J., Thakar, Monica S., Malarkannan, Subramaniam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985319/ https://www.ncbi.nlm.nih.gov/pubmed/29892299 http://dx.doi.org/10.3389/fimmu.2018.01168

Ejemplares similares

The Fyn–ADAP Axis: Cytotoxicity Versus Cytokine Production in Killer Cells
por: Gerbec, Zachary J., et al.
Publicado: (2015)

Natural Killer Cells: Development, Maturation, and Clinical Utilization
por: Abel, Alex M., et al.
Publicado: (2018)

Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome
por: Yang, Chao, et al.
Publicado: (2019)

Clinical Relevance of Natural Killer Cells Following Hematopoietic Stem Cell Transplantation
por: Palmer, Jeanne M, et al.
Publicado: (2012)

Entinostat augments NK cell functions via epigenetic upregulation of IFIT1-STING-STAT4 pathway
por: Idso, John M., et al.
Publicado: (2020)

Role of IQ Motif-Containing GTPase-Activating Proteins in Hepatocellular Carcinoma
por: Dai, Qingqing, et al.
Publicado: (2022)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

Rab7D small GTPase is involved in phago‐, trogocytosis and cytoskeletal reorganization in the enteric protozoan Entamoeba histolytica
por: Saito‐Nakano, Yumiko, et al.
Publicado: (2020)

Transcriptional Regulation of Natural Killer Cell Development and Functions
por: Wang, Dandan, et al.
Publicado: (2020)

The Cytoskeletal Protein Ndel1 Regulates Dynamin 2 GTPase Activity
por: Chansard, Mathieu, et al.
Publicado: (2011)

Functional Dichotomy between NKG2D and CD28-Mediated Co-Stimulation in Human CD8(+) T Cells
por: Rajasekaran, Kamalakannan, et al.
Publicado: (2010)

Bile Acids Induce IQ Containing GTPase Activating Protein 1 to Alleviate Liver Injury
por: Sen, Anushna, et al.
Publicado: (2021)

Comprehensive analysis of the expression and prognosis for IQ motif-containing GTPase-activating proteins in hepatocellular carcinoma
por: Dai, Qingqing, et al.
Publicado: (2022)

Controlling Cytokine Release Syndrome to Harness the Full Potential of CAR-Based Cellular Therapy
por: Thakar, Monica S., et al.
Publicado: (2020)

p21-Activated Kinase (PAK) Regulates Cytoskeletal Reorganization and Directional Migration in Human Neutrophils
por: Itakura, Asako, et al.
Publicado: (2013)

Watch the GAP: Emerging Roles for IQ Motif-Containing GTPase-Activating Proteins IQGAPs in Hepatocellular Carcinoma
por: Schmidt, Valentina A.
Publicado: (2012)

Small GTPases and formins in mammalian oocyte maturation: cytoskeletal organizers
por: Kwon, Sojung, et al.
Publicado: (2011)

Conditional Deletion of PGC-1α Results in Energetic and Functional Defects in NK Cells
por: Gerbec, Zachary J., et al.
Publicado: (2020)

IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice
por: Ghaleb, Amr M., et al.
Publicado: (2015)

Plasticity of Spine Structure: Local Signaling, Translation and Cytoskeletal Reorganization
por: Nakahata, Yoshihisa, et al.
Publicado: (2018)

Engrailed 1 coordinates cytoskeletal reorganization to induce myofibroblast differentiation
por: Györfi, Andrea-Hermina, et al.
Publicado: (2021)

267 Defining the single-cell transcriptomes of splenic adaptive Natural Killer cells in donors with latent human cytomegalovirus infection
por: Khalil, Mohamed, et al.
Publicado: (2023)

IQ Domain GTPase-Activating Protein 1 is Involved in Shear Stress-Induced Progenitor-Derived Endothelial Cell Alignment
por: Rami, Lila, et al.
Publicado: (2013)

Deciphering the biology of NKG2C+ natural killer cells
por: Rölle, Alexander
Publicado: (2015)

IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection
por: Kumar, Pawan, et al.
Publicado: (2012)

PDGF stimulation induces phosphorylation of talin and cytoskeletal reorganization in skeletal muscle
Publicado: (1993)

Ca(2+) Signaling in Cytoskeletal Reorganization, Cell Migration, and Cancer Metastasis
por: Tsai, Feng-Chiao, et al.
Publicado: (2015)

Cytoskeletal Reorganization Drives Mesenchymal Condensation and Regulates Downstream Molecular Signaling
por: Ray, Poulomi, et al.
Publicado: (2015)

Platelet activation and cytoskeletal reorganization: high voltage electron microscopic examination of intact and Triton-extracted whole mounts
Publicado: (1984)

Depletion of IQ motif-containing GTPase activating protein 2 (IQGAP2) reduces hepatic glycogen and impairs insulin signaling
por: Sen, Anushna, et al.
Publicado: (2023)

Rapamycin downregulates NKG2D ligands in acute myeloid leukemia cells via an activation of the STAT3 pathway: a potential mechanism for rapamycin-induced immune escape in leukemia
por: Zhu, Zhichao, et al.
Publicado: (2019)

Connecting G protein signaling to chemoattractant-mediated cell polarity and cytoskeletal reorganization
por: Liu, Youtao, et al.
Publicado: (2016)

Cytoskeletal Transport, Reorganization, and Fusion Regulation in Mast Cell-Stimulus Secretion Coupling
por: Ménasché, Gaël, et al.
Publicado: (2021)

Local mRNA translation and cytoskeletal reorganization: Mechanisms that tune neuronal responses
por: Triantopoulou, Nikoletta, et al.
Publicado: (2022)

Inhibitory signaling blocks activating receptor clustering and induces cytoskeletal retraction in natural killer cells
por: Abeyweera, Thushara P., et al.
Publicado: (2011)

Natural killer cell NKG2D and granzyme B are critical for allergic pulmonary inflammation(⋆)
por: Farhadi, Nazanin, et al.
Publicado: (2014)

Jak3 Enables Chemokine-Dependent Actin Cytoskeleton Reorganization by Regulating Cofilin and Rac/Rhoa GTPases Activation
por: Ambriz-Peña, Xochitl, et al.
Publicado: (2014)

NKG2A Expression Is Not per se Detrimental for the Anti-Multiple Myeloma Activity of Activated Natural Killer Cells in an In Vitro System Mimicking the Tumor Microenvironment
por: Mahaweni, Niken M., et al.
Publicado: (2018)

Electric field-directed cell shape changes, displacement, and cytoskeletal reorganization are calcium dependent
Publicado: (1988)

Role of Actin Polymerization and Adhesion to Extracellular Matrix in Rac- and Rho-induced Cytoskeletal Reorganization
por: Machesky, Laura M., et al.
Publicado: (1997)

Cannot write session to /tmp/vufind_sessions/sess_8sgl59kgladtsqd8puq700an4o