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Improved method for synthesis of low molecular weight protamine–siRNA conjugate
RNAi technology has aroused wide public interest due to its high efficiency and specificity to treat multiple types of diseases. However, the effective delivery of siRNA remains a challenge due to its large molecular weight and strong anionic charge. Considering their remarkable functions in vivo an...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985694/ https://www.ncbi.nlm.nih.gov/pubmed/29872628 http://dx.doi.org/10.1016/j.apsb.2017.11.011 |