A Testosterone Metabolite 19-Hydroxyandrostenedione Induces Neuroendocrine Trans-Differentiation of Prostate Cancer Cells via an Ectopic Olfactory Receptor

Olfactory receptor OR51E2, also known as a Prostate Specific G-Protein Receptor, is highly expressed in prostate cancer but its function is not well understood. Through in silico and in vitro analyses, we identified 24 agonists and 1 antagonist for this receptor. We detected that agonist 19-hydroxya...

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Detalles Bibliográficos
Autores principales: Abaffy, Tatjana, Bain, James R., Muehlbauer, Michael J., Spasojevic, Ivan, Lodha, Shweta, Bruguera, Elisa, O’Neal, Sara K., Kim, So Young, Matsunami, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985834/
https://www.ncbi.nlm.nih.gov/pubmed/29892571
http://dx.doi.org/10.3389/fonc.2018.00162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985834/
https://www.ncbi.nlm.nih.gov/pubmed/29892571
http://dx.doi.org/10.3389/fonc.2018.00162

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