Augmentation of the therapeutic efficacy of WEE1 kinase inhibitor AZD1775 by inhibiting the YAP–E2F1–DNA damage response pathway axis

The main reasons for failure of cancer chemotherapy are intrinsic and acquired drug resistance. The Hippo pathway effector Yes‐associated protein (YAP) is associated with resistance to both cytotoxic and molecular targeted drugs. Several lines of evidence indicate that YAP activates transcriptional...

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Detalles Bibliográficos
Autores principales: Oku, Yusuke, Nishiya, Naoyuki, Tazawa, Takaaki, Kobayashi, Takaya, Umezawa, Nanami, Sugawara, Yasuyo, Uehara, Yoshimasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986022/
https://www.ncbi.nlm.nih.gov/pubmed/29928579
http://dx.doi.org/10.1002/2211-5463.12440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986022/
https://www.ncbi.nlm.nih.gov/pubmed/29928579
http://dx.doi.org/10.1002/2211-5463.12440

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