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Conformational flexibility within the nascent polypeptide–associated complex enables its interactions with structurally diverse client proteins

As newly synthesized polypeptides emerge from the ribosome, it is crucial that they fold correctly. To prevent premature aggregation, nascent chains interact with chaperones that facilitate folding or prevent misfolding until protein synthesis is complete. Nascent polypeptide–associated complex (NAC...

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Detalles Bibliográficos
Autores principales: Martin, Esther M., Jackson, Matthew P., Gamerdinger, Martin, Gense, Karina, Karamonos, Theodoros K., Humes, Julia R., Deuerling, Elke, Ashcroft, Alison E., Radford, Sheena E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986199/
https://www.ncbi.nlm.nih.gov/pubmed/29650757
http://dx.doi.org/10.1074/jbc.RA117.001568