Regulation of PI3K signaling in T cell acute lymphoblastic leukemia: a novel PTEN/Ikaros/miR-26b mechanism reveals a critical targetable role for PIK3CD

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy, and T-ALL patients are prone to early disease relapse and suffer from poor outcomes. The PTEN, PI3K/AKT, and Notch pathways are frequently altered in T-ALL. PTEN is a tumor suppressor that inactivates the PI3K pathw...

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Detalles Bibliográficos
Autores principales: Yuan, Tian, Yang, Yaling, Chen, Jiayu, Li, Wenhui, Li, Wuping, Zhang, Qi, Mi, Yingchang, Goswami, Rashmi S., You, Jeffrey Q., Lin, Daniel, Qian, M. Diana, Calin, Steliana, Liang, Yong, Miranda, Roberto N., Calin, George A., Zhou, Xiaoyan, Ma, Li, Zweidler-McKay, Patrick A., Liu, Bin, Weng, Andrew P., Medeiros, L. Jeffrey, Zhang, Yizhuo, You, M. James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986278/
https://www.ncbi.nlm.nih.gov/pubmed/28280276
http://dx.doi.org/10.1038/leu.2017.80

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986278/
https://www.ncbi.nlm.nih.gov/pubmed/28280276
http://dx.doi.org/10.1038/leu.2017.80

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