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Regulation of PI3K signaling in T cell acute lymphoblastic leukemia: a novel PTEN/Ikaros/miR-26b mechanism reveals a critical targetable role for PIK3CD
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy, and T-ALL patients are prone to early disease relapse and suffer from poor outcomes. The PTEN, PI3K/AKT, and Notch pathways are frequently altered in T-ALL. PTEN is a tumor suppressor that inactivates the PI3K pathw...
Autores principales: | Yuan, Tian, Yang, Yaling, Chen, Jiayu, Li, Wenhui, Li, Wuping, Zhang, Qi, Mi, Yingchang, Goswami, Rashmi S., You, Jeffrey Q., Lin, Daniel, Qian, M. Diana, Calin, Steliana, Liang, Yong, Miranda, Roberto N., Calin, George A., Zhou, Xiaoyan, Ma, Li, Zweidler-McKay, Patrick A., Liu, Bin, Weng, Andrew P., Medeiros, L. Jeffrey, Zhang, Yizhuo, You, M. James |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986278/ https://www.ncbi.nlm.nih.gov/pubmed/28280276 http://dx.doi.org/10.1038/leu.2017.80 |
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