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Daily Intake of Milk Powder and Risk of Celiac Disease in Early Childhood: A Nested Case-Control Study

Milk powder and gluten are common components in Swedish infants’ diets. Whereas large intakes of gluten early in life increases the risk of celiac disease in genetically at-risk Swedish children, no study has yet evaluated if intake of milk powder by 2 years of age is associated with celiac disease....

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Autores principales: Hård af Segerstad, Elin M., Lee, Hye-Seung, Andrén Aronsson, Carin, Yang, Jimin, Uusitalo, Ulla, Sjöholm, Ingegerd, Rayner, Marilyn, Kurppa, Kalle, Virtanen, Suvi M., Norris, Jill M., Agardh, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986430/
https://www.ncbi.nlm.nih.gov/pubmed/29710789
http://dx.doi.org/10.3390/nu10050550
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author Hård af Segerstad, Elin M.
Lee, Hye-Seung
Andrén Aronsson, Carin
Yang, Jimin
Uusitalo, Ulla
Sjöholm, Ingegerd
Rayner, Marilyn
Kurppa, Kalle
Virtanen, Suvi M.
Norris, Jill M.
Agardh, Daniel
author_facet Hård af Segerstad, Elin M.
Lee, Hye-Seung
Andrén Aronsson, Carin
Yang, Jimin
Uusitalo, Ulla
Sjöholm, Ingegerd
Rayner, Marilyn
Kurppa, Kalle
Virtanen, Suvi M.
Norris, Jill M.
Agardh, Daniel
author_sort Hård af Segerstad, Elin M.
collection PubMed
description Milk powder and gluten are common components in Swedish infants’ diets. Whereas large intakes of gluten early in life increases the risk of celiac disease in genetically at-risk Swedish children, no study has yet evaluated if intake of milk powder by 2 years of age is associated with celiac disease. A 1-to-3 nested case-control study, comprised of 207 celiac disease children and 621 controls matched for sex, birth year, and HLA genotype, was performed on a birth cohort of HLA-DR3-DQ2 and/or DR4-DQ8-positive children. Subjects were screened annually for celiac disease using tissue transglutaminase autoantibodies (tTGA). Three-day food records estimated the mean intake of milk powder at ages 6 months, 9 months, 12 months, 18 months, and 24 months. Conditional logistic regression calculated odds ratios (OR) at last intake prior to seroconversion of tTGA positivity, and for each time-point respectively and adjusted for having a first-degree relative with celiac disease and gluten intake. Intake of milk powder prior to seroconversion of tTGA positivity was not associated with celiac disease (OR = 1.00; 95% CI = 0.99, 1.03; p = 0.763). In conclusion, intake of milk powder in early childhood is not associated with celiac disease in genetically susceptible children.
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spelling pubmed-59864302018-06-05 Daily Intake of Milk Powder and Risk of Celiac Disease in Early Childhood: A Nested Case-Control Study Hård af Segerstad, Elin M. Lee, Hye-Seung Andrén Aronsson, Carin Yang, Jimin Uusitalo, Ulla Sjöholm, Ingegerd Rayner, Marilyn Kurppa, Kalle Virtanen, Suvi M. Norris, Jill M. Agardh, Daniel Nutrients Article Milk powder and gluten are common components in Swedish infants’ diets. Whereas large intakes of gluten early in life increases the risk of celiac disease in genetically at-risk Swedish children, no study has yet evaluated if intake of milk powder by 2 years of age is associated with celiac disease. A 1-to-3 nested case-control study, comprised of 207 celiac disease children and 621 controls matched for sex, birth year, and HLA genotype, was performed on a birth cohort of HLA-DR3-DQ2 and/or DR4-DQ8-positive children. Subjects were screened annually for celiac disease using tissue transglutaminase autoantibodies (tTGA). Three-day food records estimated the mean intake of milk powder at ages 6 months, 9 months, 12 months, 18 months, and 24 months. Conditional logistic regression calculated odds ratios (OR) at last intake prior to seroconversion of tTGA positivity, and for each time-point respectively and adjusted for having a first-degree relative with celiac disease and gluten intake. Intake of milk powder prior to seroconversion of tTGA positivity was not associated with celiac disease (OR = 1.00; 95% CI = 0.99, 1.03; p = 0.763). In conclusion, intake of milk powder in early childhood is not associated with celiac disease in genetically susceptible children. MDPI 2018-04-28 /pmc/articles/PMC5986430/ /pubmed/29710789 http://dx.doi.org/10.3390/nu10050550 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hård af Segerstad, Elin M.
Lee, Hye-Seung
Andrén Aronsson, Carin
Yang, Jimin
Uusitalo, Ulla
Sjöholm, Ingegerd
Rayner, Marilyn
Kurppa, Kalle
Virtanen, Suvi M.
Norris, Jill M.
Agardh, Daniel
Daily Intake of Milk Powder and Risk of Celiac Disease in Early Childhood: A Nested Case-Control Study
title Daily Intake of Milk Powder and Risk of Celiac Disease in Early Childhood: A Nested Case-Control Study
title_full Daily Intake of Milk Powder and Risk of Celiac Disease in Early Childhood: A Nested Case-Control Study
title_fullStr Daily Intake of Milk Powder and Risk of Celiac Disease in Early Childhood: A Nested Case-Control Study
title_full_unstemmed Daily Intake of Milk Powder and Risk of Celiac Disease in Early Childhood: A Nested Case-Control Study
title_short Daily Intake of Milk Powder and Risk of Celiac Disease in Early Childhood: A Nested Case-Control Study
title_sort daily intake of milk powder and risk of celiac disease in early childhood: a nested case-control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986430/
https://www.ncbi.nlm.nih.gov/pubmed/29710789
http://dx.doi.org/10.3390/nu10050550
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