Transcriptional activation of p21(Waf1) contributes to suppression of HR by p53 in response to replication arrest induced by camptothecin

The inhibitory effect of p53 on homologous recombination (HR) is exerted through sequestration of replication protein A (RPA). Release of the p53/RPA complex in response to replication stress is crucially dependent on the phosphorylation status of both proteins and is required for efficient DNA repa...

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Detalles Bibliográficos
Autores principales: Romanova, Larisa Y., Mushinski, Frederick, Kovalchuk, Alexander L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986631/
https://www.ncbi.nlm.nih.gov/pubmed/29875999
http://dx.doi.org/10.18632/oncotarget.25172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986631/
https://www.ncbi.nlm.nih.gov/pubmed/29875999
http://dx.doi.org/10.18632/oncotarget.25172

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