Melanoma-associated mutants within the serine-rich domain of PAK5 direct kinase activity to mitogenic pathways

The overexpression and hyperactivity of p21-activated serine/threonine kinases (PAKs) is known to facilitate tumorigenesis; however, the contribution of cancer-associated PAK mutations to tumor initiation and progression remains unclear. Here, we identify p21-activated serine/threonine kinase 5 (PAK...

Descripción completa

Detalles Bibliográficos
Autores principales: LaPak, Kyle M., Vroom, Dennis C., Garg, Ayush A., Guan, Xiangnan, Hays, John L., Song, Jonathan W., Burd, Christin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986637/
https://www.ncbi.nlm.nih.gov/pubmed/29875996
http://dx.doi.org/10.18632/oncotarget.25356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986637/
https://www.ncbi.nlm.nih.gov/pubmed/29875996
http://dx.doi.org/10.18632/oncotarget.25356

Ejemplares similares