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Melanoma-associated mutants within the serine-rich domain of PAK5 direct kinase activity to mitogenic pathways

The overexpression and hyperactivity of p21-activated serine/threonine kinases (PAKs) is known to facilitate tumorigenesis; however, the contribution of cancer-associated PAK mutations to tumor initiation and progression remains unclear. Here, we identify p21-activated serine/threonine kinase 5 (PAK...

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Detalles Bibliográficos
Autores principales:	LaPak, Kyle M., Vroom, Dennis C., Garg, Ayush A., Guan, Xiangnan, Hays, John L., Song, Jonathan W., Burd, Christin E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986637/ https://www.ncbi.nlm.nih.gov/pubmed/29875996 http://dx.doi.org/10.18632/oncotarget.25356

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