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Engineering of a rough auxotrophic mutant Salmonella Typhimurium for effective delivery

Live Salmonella vaccine vectors offer a remarkable platform for delivering immunogens and therapeutic molecules by mimicking natural intracellular infections; however, pre-existing anti-vector immunity can impede effective deployment. Measures to alleviate pre-existing immunity include the use of he...

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Detalles Bibliográficos
Autores principales: Lalsiamthara, Jonathan, Kim, Je Hyoung, Lee, John Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986645/
https://www.ncbi.nlm.nih.gov/pubmed/29876000
http://dx.doi.org/10.18632/oncotarget.25192