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Altered membrane rigidity via enhanced endogenous cholesterol synthesis drives cancer cell resistance to destruxins
Destruxins, secondary metabolites of entomopathogenic fungi, exert a wide variety of interesting characteristics ranging from antiviral to anticancer effects. Although their mode of action was evaluated previously, the molecular mechanisms of resistance development are unknown. Hence, we have establ...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986646/ https://www.ncbi.nlm.nih.gov/pubmed/29876015 http://dx.doi.org/10.18632/oncotarget.25432 |