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Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling
Altered mitochondrial metabolism acts as an initial cause for cardiovascular diseases and metabolic intermediate succinate emerges as a mediator of mitochondrial dysfunction. This work aims to investigate whether or not extracellular succinate accumulation and its targeted G protein-coupled receptor...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986788/ https://www.ncbi.nlm.nih.gov/pubmed/29867110 http://dx.doi.org/10.1038/s41419-018-0708-5 |