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Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling

Altered mitochondrial metabolism acts as an initial cause for cardiovascular diseases and metabolic intermediate succinate emerges as a mediator of mitochondrial dysfunction. This work aims to investigate whether or not extracellular succinate accumulation and its targeted G protein-coupled receptor...

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Detalles Bibliográficos
Autores principales:	Lu, Yi-Tong, Li, Lan-Zhu, Yang, Yi-Lin, Yin, Xiaojian, Liu, Qun, Zhang, Lei, Liu, Kang, Liu, Baolin, Li, Jia, Qi, Lian-Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986788/ https://www.ncbi.nlm.nih.gov/pubmed/29867110 http://dx.doi.org/10.1038/s41419-018-0708-5

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