Blockade of Endothelin-1 Receptor Type B Ameliorates Glucose Intolerance and Insulin Resistance in a Mouse Model of Obstructive Sleep Apnea

Obstructive sleep apnea (OSA) is associated with insulin resistance (IR) and glucose intolerance. Elevated endothelin-1 (ET-1) levels have been observed in OSA patients and in mice exposed to intermittent hypoxia (IH). We examined whether pharmacological blockade of type A and type B ET-1 receptors...

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Detalles Bibliográficos
Autores principales: Polak, Jan, Punjabi, Naresh M., Shimoda, Larissa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986958/
https://www.ncbi.nlm.nih.gov/pubmed/29896159
http://dx.doi.org/10.3389/fendo.2018.00280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986958/
https://www.ncbi.nlm.nih.gov/pubmed/29896159
http://dx.doi.org/10.3389/fendo.2018.00280

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