Porcupine inhibitors impair trabecular and cortical bone mass and strength in mice

WNT signaling is involved in the tumorigenesis of various cancers and regulates bone homeostasis. Palmitoleoylation of WNTs by Porcupine is required for WNT activity. Porcupine inhibitors are under development for cancer therapy. As the possible side effects of Porcupine inhibitors on bone health ar...

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Detalles Bibliográficos
Autores principales: Funck-Brentano, Thomas, Nilsson, Karin H, Brommage, Robert, Henning, Petra, Lerner, Ulf H, Koskela, Antti, Tuukkanen, Juha, Cohen-Solal, Martine, Movérare-Skrtic, Sofia, Ohlsson, Claes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987170/
https://www.ncbi.nlm.nih.gov/pubmed/29720540
http://dx.doi.org/10.1530/JOE-18-0153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987170/
https://www.ncbi.nlm.nih.gov/pubmed/29720540
http://dx.doi.org/10.1530/JOE-18-0153

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