Cargando…

Porcupine inhibitors impair trabecular and cortical bone mass and strength in mice

WNT signaling is involved in the tumorigenesis of various cancers and regulates bone homeostasis. Palmitoleoylation of WNTs by Porcupine is required for WNT activity. Porcupine inhibitors are under development for cancer therapy. As the possible side effects of Porcupine inhibitors on bone health ar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Funck-Brentano, Thomas, Nilsson, Karin H, Brommage, Robert, Henning, Petra, Lerner, Ulf H, Koskela, Antti, Tuukkanen, Juha, Cohen-Solal, Martine, Movérare-Skrtic, Sofia, Ohlsson, Claes
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bioscientifica Ltd 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987170/ https://www.ncbi.nlm.nih.gov/pubmed/29720540 http://dx.doi.org/10.1530/JOE-18-0153

Ejemplares similares

Estradiol and RSPO3 regulate vertebral trabecular bone mass independent of each other
por: Nilsson, Karin H., et al.
Publicado: (2022)

Osteoblast-derived NOTUM reduces cortical bone mass in mice and the NOTUM locus is associated with bone mineral density in humans
por: Movérare-Skrtic, Sofia, et al.
Publicado: (2019)

Inducible Wnt16 inactivation: WNT16 regulates cortical bone thickness in adult mice
por: Ohlsson, Claes, et al.
Publicado: (2018)

Bone-Derived IGF-I Regulates Radial Bone Growth in Adult Male Mice
por: Svensson, Johan, et al.
Publicado: (2023)

RSPO3 is important for trabecular bone and fracture risk in mice and humans
por: Nilsson, Karin H., et al.
Publicado: (2021)

Wnt16 Overexpression in Osteoblasts Increases the Subchondral Bone Mass but has no Impact on Osteoarthritis in Young Adult Female Mice
por: Törnqvist, Anna E., et al.
Publicado: (2020)

Causal Factors for Knee, Hip, and Hand Osteoarthritis: A Mendelian Randomization Study in the UK Biobank
por: Funck‐Brentano, Thomas, et al.
Publicado: (2019)

Clinically relevant doses of vitamin A decrease cortical bone mass in mice
por: Lionikaite, Vikte, et al.
Publicado: (2018)

SERMs have substance-specific effects on bone, and these effects are mediated via ERαAF-1 in female mice
por: Börjesson, Anna E., et al.
Publicado: (2016)

An atlas of genetic determinants of forearm fracture
por: Nethander, Maria, et al.
Publicado: (2023)

WNT16 is Robustly Increased by Oncostatin M in Mouse Calvarial Osteoblasts and Acts as a Negative Feedback Regulator of Osteoclast Formation Induced by Oncostatin M
por: Henning, Petra, et al.
Publicado: (2021)

Induced inactivation of Wnt16 in young adult mice has no impact on osteoarthritis development
por: Törnqvist, Anna E., et al.
Publicado: (2022)

Anti-Sclerostin Antibodies in Osteoporosis and Other Bone Diseases
por: Fabre, Stéphanie, et al.
Publicado: (2020)

Probiotics Protect Mice from Ovariectomy-Induced Cortical Bone Loss
por: Ohlsson, Claes, et al.
Publicado: (2014)

The role of membrane ERα signaling in bone and other major estrogen responsive tissues
por: Gustafsson, K. L., et al.
Publicado: (2016)

Bone fragility in patients with chronic kidney disease
por: Cohen-Solal, Martine, et al.
Publicado: (2020)

The Bone Sparing Effects of 2-Methoxyestradiol Are Mediated via Estrogen Receptor-α in Male Mice
por: Eriksson, Anna L., et al.
Publicado: (2016)

NOTUM inhibition increases endocortical bone formation and bone strength
por: Brommage, Robert, et al.
Publicado: (2019)

Acute fat loss does not affect bone mass
por: Lagerquist, Marie K., et al.
Publicado: (2021)

High-Sensitivity CRP Is an Independent Risk Factor for All Fractures and Vertebral Fractures in Elderly Men: The MrOS Sweden Study
por: Eriksson, Anna L, et al.
Publicado: (2014)

Global Wnt Inhibition With a Porcupine Inhibitor Decreases Established Trabecular Bone in a Mouse Model of Fibrous Dysplasia
por: Lung, Hsuan, et al.
Publicado: (2021)

High Fidelity of Mouse Models Mimicking Human Genetic Skeletal Disorders
por: Brommage, Robert, et al.
Publicado: (2020)

Membrane estrogen receptor α signaling modulates the sensitivity to estradiol treatment in a dose- and tissue- dependent manner
por: Jiang, Yiwen, et al.
Publicado: (2023)

Reduced Bone Mass and Muscle Strength in Male 5α-Reductase Type 1 Inactivated Mice
por: Windahl, Sara H., et al.
Publicado: (2011)

Phosphorylation of S122 in ERα is important for the skeletal response to estrogen treatment in male mice
por: Horkeby, Karin, et al.
Publicado: (2022)

Effect of C282Y Genotype on Self-Reported Musculoskeletal Complications in Hereditary Hemochromatosis
por: Camacho, António, et al.
Publicado: (2015)

Evidence of scavenging behaviour in crested porcupine
por: Coppola, Francesca, et al.
Publicado: (2020)

A tissue-specific role of membrane-initiated ERα signaling for the effects of SERMs
por: Gustafsson, Karin L, et al.
Publicado: (2022)

BMD-Related Genetic Risk Scores Predict Site-Specific Fractures as Well as Trabecular and Cortical Bone Microstructure
por: Nethander, Maria, et al.
Publicado: (2020)

Young Adult Male Patients With Childhood-onset IBD Have Increased Risks of Compromised Cortical and Trabecular Bone Microstructures
por: Sigurdsson, Gudmundur Vignir, et al.
Publicado: (2022)

Loss of sclerostin promotes osteoarthritis in mice via β-catenin-dependent and -independent Wnt pathways
por: Bouaziz, Wafa, et al.
Publicado: (2015)

More severe phenotype of early‐onset osteoporosis associated with recessive form of LRP5 and combination with DKK1 or WNT3A
por: Caetano da Silva, Caroline, et al.
Publicado: (2021)

Genetic Determinants of Trabecular and Cortical Volumetric Bone Mineral Densities and Bone Microstructure
por: Paternoster, Lavinia, et al.
Publicado: (2013)

Porcupine: A visual pipeline tool for neuroimaging analysis
por: van Mourik, Tim, et al.
Publicado: (2018)

Interspecific Aggressions between Crested Porcupines and Roe Deer
por: Lazzeri, Lorenzo, et al.
Publicado: (2020)

Spatial ecology of crested porcupine in a metropolitan landscape
por: Mori, Emiliano, et al.
Publicado: (2022)

SUN-744 Phosphorylation Site S122 in Estrogen Receptor α Has a Tissue-Dependent Role in Female Mice
por: Gustafsson, Karin L, et al.
Publicado: (2020)

Attainment of Brown Adipocyte Features in White Adipocytes of Hormone-Sensitive Lipase Null Mice
por: Ström, Kristoffer, et al.
Publicado: (2008)

Estren promotes androgen phenotypes in primary lymphoid organs and submandibular glands
por: Islander, Ulrika, et al.
Publicado: (2005)

Structure Model Index Does Not Measure Rods and Plates in Trabecular Bone
por: Salmon, Phil L., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_5h8s9vju447ofld3a6s060fevo