CDK5 Inhibition Resolves PKA/cAMP-Independent Activation of CREB1 Signaling in Glioma Stem Cells

Cancer stem cells promote neoplastic growth, in part by deregulating asymmetric cell division and enhancing self-renewal. To uncover mechanisms and potential therapeutic targets in glioma stem cell (GSC) self-renewal, we performed a genetic suppressor screen for kinases to reverse the tumor phenotyp...

Descripción completa

Detalles Bibliográficos
Autores principales: Mukherjee, Subhas, Tucker-Burden, Carol, Kaissi, Emily, Newsam, Austin, Duggireddy, Hithardhi, Chau, Monica, Zhang, Changming, Diwedi, Bhakti, Rupji, Manali, Seby, Sandra, Kowalski, Jeanne, Kong, Jun, Read, Renee, Brat, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987254/
https://www.ncbi.nlm.nih.gov/pubmed/29742423
http://dx.doi.org/10.1016/j.celrep.2018.04.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987254/
https://www.ncbi.nlm.nih.gov/pubmed/29742423
http://dx.doi.org/10.1016/j.celrep.2018.04.016

Ejemplares similares