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Intracellular signalling pathways and cytoskeletal functions converge on the psoriasis candidate gene CCHCR1 expressed at P-bodies and centrosomes

BACKGROUND: CCHCR1 (Coiled-Coil α-Helical Rod protein 1) is a putative psoriasis candidate gene with the risk alleles CCHCR1*WWCC and *Iso3, the latter inhibiting the translation of isoform 1. CCHCR1 was recently shown to be a centrosomal protein, as well as a component of cytoplasmic processing bod...

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Detalles Bibliográficos
Autores principales: Tervaniemi, Mari H., Katayama, Shintaro, Skoog, Tiina, Siitonen, H. Annika, Vuola, Jyrki, Nuutila, Kristo, Tammimies, Kristiina, Suomela, Sari, Kankuri, Esko, Kere, Juha, Elomaa, Outi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987482/
https://www.ncbi.nlm.nih.gov/pubmed/29866042
http://dx.doi.org/10.1186/s12864-018-4810-y