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Knockdown of asporin affects transforming growth factor-β1-induced matrix synthesis in human intervertebral annulus cells
BACKGROUND/OBJECTIVE: Asporin is associated with osteoarthritis and lumbar disk degeneration. Previous studies in chondrocytes showed that asporin can bind to transforming growth factor-β1 (TGF-β1) and downregulate matrix biosynthesis. However, this has not been studied in intervertebral disk (IVD)...
Autores principales: | Jiang, Xu, Wu, Cheng Ai, Wang, Ying, Shi, Ke-Jian, Jiang, Xiao-Zhou, Zheng, Shan, Tian, Wei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chinese Speaking Orthopaedic Society
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987567/ https://www.ncbi.nlm.nih.gov/pubmed/30035083 http://dx.doi.org/10.1016/j.jot.2016.05.011 |
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