PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo

Genetic ablation of the tumor suppressor PTEN in prostatic epithelial cells (PECs) induces cell senescence. However, unlike oncogene-induced senescence, no hyperproliferation phase and no signs of DNA damage response (DDR) were observed in PTEN-deficient PECs; PTEN loss-induced senescence (PICS) was...

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Detalles Bibliográficos
Autores principales: Parisotto, Maxime, Grelet, Elise, El Bizri, Rana, Dai, Yongyuan, Terzic, Julie, Eckert, Doriane, Gargowitsch, Laetitia, Bornert, Jean-Marc, Metzger, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987915/
https://www.ncbi.nlm.nih.gov/pubmed/29743291
http://dx.doi.org/10.1084/jem.20171207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987915/
https://www.ncbi.nlm.nih.gov/pubmed/29743291
http://dx.doi.org/10.1084/jem.20171207

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