Cargando…

PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo

Genetic ablation of the tumor suppressor PTEN in prostatic epithelial cells (PECs) induces cell senescence. However, unlike oncogene-induced senescence, no hyperproliferation phase and no signs of DNA damage response (DDR) were observed in PTEN-deficient PECs; PTEN loss-induced senescence (PICS) was...

Descripción completa

Detalles Bibliográficos
Autores principales:	Parisotto, Maxime, Grelet, Elise, El Bizri, Rana, Dai, Yongyuan, Terzic, Julie, Eckert, Doriane, Gargowitsch, Laetitia, Bornert, Jean-Marc, Metzger, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987915/ https://www.ncbi.nlm.nih.gov/pubmed/29743291 http://dx.doi.org/10.1084/jem.20171207

Ejemplares similares

Hypoxia-mediated stabilization of HIF1A in prostatic intraepithelial neoplasia promotes cell plasticity and malignant progression
por: Abu el Maaty, Mohamed A., et al.
Publicado: (2022)

Single-cell analyses unravel cell type–specific responses to a vitamin D analog in prostatic precancerous lesions
por: Abu el Maaty, Mohamed A., et al.
Publicado: (2021)

Klf5 Deletion Promotes Pten Deletion–Initiated Luminal-Type Mouse Prostate Tumors through Multiple Oncogenic Signaling Pathways()()
por: Xing, Changsheng, et al.
Publicado: (2014)

Hypoxia‐inducible factor 1A inhibition overcomes castration resistance of prostate tumors
por: Terzic, Julie, et al.
Publicado: (2023)

TIP5 primes prostate luminal cells for the oncogenic transformation mediated by PTEN-loss
por: Pietrzak, Karolina, et al.
Publicado: (2020)

Inference of tissue relative proportions of the breast epithelial cell types luminal progenitor, basal, and luminal mature
por: Bartlett, Thomas E., et al.
Publicado: (2021)

Characteristics of the Epididymal Luminal Environment Responsible for Sperm Maturation and Storage
por: Zhou, Wei, et al.
Publicado: (2018)

Broccoli, PTEN deletion and prostate cancer: where is the link?
por: Appendino, Giovanni, et al.
Publicado: (2010)

Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice
por: Kibe, Ryoko, et al.
Publicado: (2014)

The effect Akt2 deletion on tumor development in Pten(+/−) mice
por: Xu, P-Z, et al.
Publicado: (2012)

PTEN Deletion Enhances the Regenerative Ability of Adult Corticospinal Neurons
por: Liu, Kai, et al.
Publicado: (2010)

Partial PTEN deletion is linked to poor prognosis in breast cancer
por: Lebok, P., et al.
Publicado: (2015)

Clinical Significance of PTEN Deletion, Mutation, and Loss of PTEN Expression in De Novo Diffuse Large B-Cell Lymphoma
por: Wang, Xiaoxiao, et al.
Publicado: (2018)

Deletion of the mitochondria-shaping protein Opa1 during early thymocyte maturation impacts mature memory T cell metabolism
por: Corrado, Mauro, et al.
Publicado: (2021)

Sustained axon regeneration induced by co-deletion of PTEN and SOCS3
por: Sun, Fang, et al.
Publicado: (2011)

An intronic polymorphic deletion in the PTEN gene: implications for molecular diagnostic testing
por: Sandell, S, et al.
Publicado: (2013)

PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors
por: Smith, Amanda M., et al.
Publicado: (2019)

Circumventing senescence is associated with stem cell properties and metformin sensitivity
por: Deschênes‐Simard, Xavier, et al.
Publicado: (2019)

NFATc1 Promotes Prostate Tumorigenesis and Overcomes PTEN Loss-Induced Senescence
por: Manda, Kalyan R., et al.
Publicado: (2015)

The impact of PIK3CA mutations and PTEN expression on the effect of neoadjuvant therapy for postmenopausal luminal breast cancer patients
por: Hayama, Shouko, et al.
Publicado: (2023)

Deletion of MEC1 suppresses the replicative senescence of the cdc13-2 mutant in Saccharomyces cerevisiae
por: Yao, Yue, et al.
Publicado: (2023)

Impaired Luminal Control of Intestinal Macrophage Maturation in Patients With Ulcerative Colitis During Remission
por: Maasfeh, Lujain, et al.
Publicado: (2021)

PTEN inhibits replicative senescence‐induced MMP‐1 expression by regulating NOX4‐mediated ROS in human dermal fibroblasts
por: Noh, Eun‐Mi, et al.
Publicado: (2017)

THE TOTAL LUMINOUS EFFICIENCY OF LUMINOUS BACTERIA
por: Harvey, E. Newton
Publicado: (1925)

Deletion of PTEN produces autism-like behavioral deficits and alterations in synaptic proteins
por: Lugo, Joaquin N., et al.
Publicado: (2014)

Erratum: PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors
por: Smith, Amanda M., et al.
Publicado: (2020)

Lipidomics dataset of PTEN deletion-induced optic nerve regeneration mouse model
por: Arcuri, Jennifer, et al.
Publicado: (2020)

PTEN Deletion in Adult Mice Induces Hypoinsulinemia With Concomitant Low Glucose Levels
por: Crespo-Masip, Maria, et al.
Publicado: (2022)

PEDF Deletion Induces Senescence and Defects in Phagocytosis in the RPE
por: Rebustini, Ivan T., et al.
Publicado: (2022)

Time-dependent replicative senescence vs. disturbed flow-induced pre-mature aging in atherosclerosis
por: Dominic, Abishai, et al.
Publicado: (2020)

Sox2 is necessary for androgen ablation-induced neuroendocrine differentiation from Pten null Sca-1(+) prostate luminal cells
por: Kwon, Oh-Joon, et al.
Publicado: (2020)

Anti‐oncogenic PTEN induces ovarian cancer cell senescence by targeting P21
por: Ke, Xiaoping, et al.
Publicado: (2021)

Coordinate Regulation of Mature Dopaminergic Axon Morphology by Macroautophagy and the PTEN Signaling Pathway
por: Inoue, Keiichi, et al.
Publicado: (2013)

Decreased nuclear Pten in neural stem cells contributes to deficits in neuronal maturation
por: Kang, Shin Chung, et al.
Publicado: (2020)

Evidence of oxidative stress-induced senescence in mature, post-mature and pathological human placentas
por: Cindrova-Davies, Tereza, et al.
Publicado: (2018)

Genomic Deletion at 10q23 in Prostate Cancer: More Than PTEN Loss?
por: Poluri, Raghavendra Tejo Karthik, et al.
Publicado: (2018)

AKT-dependent and -independent pathways mediate PTEN deletion-induced CNS axon regeneration
por: Huang, Haoliang, et al.
Publicado: (2019)

Up-regulation of Biglycan is Associated with Poor Prognosis and PTEN Deletion in Patients with Prostate Cancer
por: Jacobsen, Frank, et al.
Publicado: (2017)

Double Deletion of PI3K and PTEN Modifies Lens Postnatal Growth and Homeostasis
por: Sellitto, Caterina, et al.
Publicado: (2022)

Targeting mTOR Pathway in PTEN Deleted Newly Isolated Chordoma Cell Line
por: Pagani, Francesca, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_j8gg05l5id7mncaajbmae47jc4