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Cholesterol negatively regulates IL-9–producing CD8(+) T cell differentiation and antitumor activity
CD8(+) T cells can be polarized into IL-9–secreting (Tc9) cells. We previously showed that adoptive therapy using tumor-specific Tc9 cells generated stronger antitumor responses in mouse melanoma than classical Tc1 cells. To understand why Tc9 cells exert stronger antitumor responses, we used gene p...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987919/ https://www.ncbi.nlm.nih.gov/pubmed/29743292 http://dx.doi.org/10.1084/jem.20171576 |