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Less cholesterol means better tumor killing for cytotoxic T9 cells

In this issue, Ma et al. (https://doi.org/10.1084/jem.20171576) show that removal of cholesterol from CD8 T cells during type 9 differentiation increases their IL-9 production, persistence in vivo, and cytolytic function against tumors by preventing SUMOylation of liver X receptors.

Detalles Bibliográficos
Autores principales: Griesenauer, Brad, Paczesny, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987929/
https://www.ncbi.nlm.nih.gov/pubmed/29764914
http://dx.doi.org/10.1084/jem.20180852