Less cholesterol means better tumor killing for cytotoxic T9 cells

In this issue, Ma et al. (https://doi.org/10.1084/jem.20171576) show that removal of cholesterol from CD8 T cells during type 9 differentiation increases their IL-9 production, persistence in vivo, and cytolytic function against tumors by preventing SUMOylation of liver X receptors.

Detalles Bibliográficos
Autores principales: Griesenauer, Brad, Paczesny, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
News
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987929/
https://www.ncbi.nlm.nih.gov/pubmed/29764914
http://dx.doi.org/10.1084/jem.20180852
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author Griesenauer, Brad
Paczesny, Sophie
author_facet Griesenauer, Brad
Paczesny, Sophie
author_sort Griesenauer, Brad
collection PubMed
description In this issue, Ma et al. (https://doi.org/10.1084/jem.20171576) show that removal of cholesterol from CD8 T cells during type 9 differentiation increases their IL-9 production, persistence in vivo, and cytolytic function against tumors by preventing SUMOylation of liver X receptors.
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spelling pubmed-59879292018-12-04 Less cholesterol means better tumor killing for cytotoxic T9 cells Griesenauer, Brad Paczesny, Sophie J Exp Med News In this issue, Ma et al. (https://doi.org/10.1084/jem.20171576) show that removal of cholesterol from CD8 T cells during type 9 differentiation increases their IL-9 production, persistence in vivo, and cytolytic function against tumors by preventing SUMOylation of liver X receptors. Rockefeller University Press 2018-06-04 /pmc/articles/PMC5987929/ /pubmed/29764914 http://dx.doi.org/10.1084/jem.20180852 Text en © 2018 Griesenauer and Paczesny http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle News
Griesenauer, Brad
Paczesny, Sophie
Less cholesterol means better tumor killing for cytotoxic T9 cells
title Less cholesterol means better tumor killing for cytotoxic T9 cells
title_full Less cholesterol means better tumor killing for cytotoxic T9 cells
title_fullStr Less cholesterol means better tumor killing for cytotoxic T9 cells
title_full_unstemmed Less cholesterol means better tumor killing for cytotoxic T9 cells
title_short Less cholesterol means better tumor killing for cytotoxic T9 cells
title_sort less cholesterol means better tumor killing for cytotoxic t9 cells
topic News
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987929/
https://www.ncbi.nlm.nih.gov/pubmed/29764914
http://dx.doi.org/10.1084/jem.20180852
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AT paczesnysophie lesscholesterolmeansbettertumorkillingforcytotoxict9cells

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