Crystal structures of the PH domains from Lbc family of RhoGEFs bound to activated RhoA GTPase

The Pleckstrin homology (PH) domains from the Lbc family of Rho Guanine Nucleotide Exchange Factors (Lbc RhoGEFs) interact with activated Rho family GTPases. All 7 Lbc RhoGEFs associate directly with activated Rho GTPases via their PH domains. However, the binding affinities between the PH domains a...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Zhe, Gutowski, Steven, Sternweis, Paul C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Cell biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988292/
https://www.ncbi.nlm.nih.gov/pubmed/29876405
http://dx.doi.org/10.1016/j.dib.2018.01.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988292/
https://www.ncbi.nlm.nih.gov/pubmed/29876405
http://dx.doi.org/10.1016/j.dib.2018.01.024

Ejemplares similares