Genetic abrogation of the fibronectin-α5β1 integrin interaction in articular cartilage aggravates osteoarthritis in mice

The balance between synthesis and degradation of the cartilage extracellular matrix is severely altered in osteoarthritis, where degradation predominates. One reason for this imbalance is believed to be due to the ligation of the α5β1 integrin, the classic fibronectin (FN) receptor, with soluble FN...

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Detalles Bibliográficos
Autores principales: Almonte-Becerril, Maylin, Gimeno-LLuch, Irene, Villarroya, Olga, Benito-Jardón, María, Kouri, Juan Bautista, Costell, Mercedes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988303/
https://www.ncbi.nlm.nih.gov/pubmed/29870552
http://dx.doi.org/10.1371/journal.pone.0198559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988303/
https://www.ncbi.nlm.nih.gov/pubmed/29870552
http://dx.doi.org/10.1371/journal.pone.0198559

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