SHMT2 and the BRCC36/BRISC deubiquitinase regulate HIV-1 Tat K63-ubiquitylation and destruction by autophagy

HIV-1 Tat is a key regulator of viral transcription, however little is known about the mechanisms that control its turnover in T cells. Here we use a novel proteomics technique, called DiffPOP, to identify the molecular target of JIB-04, a small molecule compound that potently and selectively blocks...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Muyu, Moresco, James J., Chang, Max, Mukim, Amey, Smith, Davey, Diedrich, Jolene K., Yates, John R., Jones, Katherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988312/
https://www.ncbi.nlm.nih.gov/pubmed/29791506
http://dx.doi.org/10.1371/journal.ppat.1007071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988312/
https://www.ncbi.nlm.nih.gov/pubmed/29791506
http://dx.doi.org/10.1371/journal.ppat.1007071

Ejemplares similares