Cryo-EM shows how dynactin recruits two dyneins for faster movement

Dynein and its cofactor dynactin form a highly processive microtubule motor in the presence of an activating adaptor, such as BICD2. Different adaptors link dynein/dynactin to distinct cargos. Here we use electron microscopy (EM) and single molecule studies to show that adaptors can recruit a second...

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Detalles Bibliográficos
Autores principales: Urnavicius, Linas, Lau, Clinton K., Elshenawy, Mohamed M., Morales-Rios, Edgar, Motz, Carina, Yildiz, Ahmet, Carter, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988349/
https://www.ncbi.nlm.nih.gov/pubmed/29420470
http://dx.doi.org/10.1038/nature25462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988349/
https://www.ncbi.nlm.nih.gov/pubmed/29420470
http://dx.doi.org/10.1038/nature25462

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